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Description

Biomaterials 33 (19), 4889-4906

Sheu M, Yang C, Pan L, Sheehan J, Pan L, You W, et al

Using gene-edited mice with humanised GLP-1 receptors, the team found that oral small-molecule GLP-1 drugs activated the central amygdala, a region associated with desire and reward that sits deeper in the brain than the hypothalamic and hindbrain networks where injectable peptide GLP-1s have been shown to act