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Decreased appetite may occur in some patients and can become problematic if it leads to inadequate nutritional intake

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As a result, millions of beneficiaries may become eligible for therapies that were previously out of reach

This finding highlights a fundamental distinction that must be applied when interpreting the preclinical literature as a whole: the majority of studies reporting positive outcomes employed a preventive or co-treatment paradigm, in which the drug was administered prior to or concurrently with pathological induction