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Some of the objective , anatomic improvements seen on Meibomian gland imaging are elongation of previously shortened glands, previously thin glands becoming wider, more robust and healthier, and regeneration of previously lost or missing glands

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Gender women are about twice as likely to experience depression as men Age adolescents and young adults are more likely to develop depression than older adults, and the risk is especially high in gender- and sexual-minority, racial- and ethnic-minority, and economically disadvantaged youth Family history of depression the risk of major depression is three times greater among those who have a first-degree relative with major depression Maltreatment during childhood, including neglect and abuse Adverse life events, such as unemployment, financial hardship, divorce, grief and loss, and catastrophic world events such as natural disasters Chronic or severe stress Loneliness Certain personality traits, including shyness, agreeableness, and moodiness Sleep disorders, including sleep apnea Other psychiatric disorders, such as substance use disorders, anxiety disorders, and post-traumatic stress disorder (PTSD) Depression frequently co-occurs with chronic diseases: stroke survivors and people with chronic diseases like heart disease, cancer, diabetes, and respiratory disease are up to four times more likely than others to have depression, and the co-occurrence of depression worsens their prognosis

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