comparison of glp-1 agonists compare glp 1 drugs Table 1 from Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Drug Class Review Free Comparison Chart: Treatment with GLP-1 Receptor Agonists

& Finkel, T

When administered, the peptide preferentially accumulates in adipose tissue, where it interacts with beta-3 adrenergic receptors on fat cell membranes and initiates metabolic signaling cascades

Hepatic 25-hydroxylation via cytochrome P450 isoform CYP2R1 converts cholecalciferol to 25(OH)D, followed by renal 1-hydroxylation through CYP27B1 to yield bioactive 1,25(OH)2D [153]

Parameters to monitor History of depression (reserpine) Sleep disturbances, drowsiness, and lethargy (reserpine) Symptoms of peptic ulcer (reserpine) Centrally active 2 -agonists See Table 12-10 for a list of centrally active 2 -agonists, their usual dosage range, and adverse effects associated with these medications