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Kristen Kistler MS, RD, LDN, outpatient dietitian at Ochsner LSU Health
The latest research indicates that high concentrations of intracellular lactate during sepsis serve not only as an energy source but also as an epigenetic modifier, leading to lactylation modification at lysine 18 of histone H3 (H3K18la) ( Concurrently, succinate accumulation caused by the interruption of the TCA cycle triggers widespread protein succinylation
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