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Christensen M, Vedtofte L, Holst JJ, Vilsboll T, Knop FK (2011) Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans

The peptide activates the PI3K/Akt signaling cascade, leading to translocation of GLUT4 glucose transporters to the cell membrane and increased cellular glucose uptake

The rates of invasive recurrence and metastatic disease were high in both groups, but the researchers found that people using GLP-1s had a 74% lower risk of invasive or metastatic cancer progression

4,7 Diagnosis The diagnosis of SJS/TEN is based on a history of drug exposure along with clinical evidence of classic mucocutaneous lesions