When glucagon receptor agonism is layered on top of GLP-1 and GIP activity, the theory is that you are not just reducing caloric intake through appetite suppression you are also increasing the rate at which the body burns energy, particularly fat stored in the liver
The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4
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