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This unpaired electron results in high instability and reactivity of the free radical leading to oxidation or reduction of the biomolecules
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And the TMD is responsible for further interaction with the N-terminus of the ligand, which triggers receptor activation ( FIGURE 1 GLP-1R is found mainly on the cell membranes of different cell types in the human body
Consequently, ECL1 adopted a more relaxed conformation, making peptide 20 straighter by shifting its tip toward the transmembrane domain (TMD) core by 4.2 (measured by the C of L27 P )
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