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As chronic PE induces tissue changes that go beyond skeletal muscle tissue (e.g., increase in mitochondria in adipose tissue), it is plausible that changes such as improvement in mitochondrial metabolism (improves their structure and function) in the epidermis also could occur in response to physical training practice (see Figure 6)
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We have also found that pretreatment of GHK-Cu has a robust antioxidant effect in WI-38 cells treated with 150uM of hydrogen peroxide, decreasing the ROS level to almost 60 percent (Figure 1)
This decline is often what leads people to look toward supplementation to bridge the gap
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