The main difference in GHK-Cu vs BPC-157 is that GHK-Cu is more often associated with collagen and skin regeneration pathways, while BPC-157 is more often associated with tendon, ligament, muscle, gut, and systemic recovery pathways
In isolated rat aorta preparations, the peptide produced concentration-dependent vasodilation that was endothelium-dependent and abolished by L-NAME, and co-immunoprecipitation work traced the response to phosphorylation of Src, caveolin-1, and endothelial nitric oxide synthase, with reduced binding between caveolin-1 and eNOS [1]
The medical use of peptides dates back to the 1920s with the isolation of insulin, which transformed diabetes care
A 3.0 ml reconstitution gives a less concentrated solution, which is often easier to measure consistently on a U-100 insulin syringe