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Proteins and fats are the other major alimentary constituents fermented by gut microbiota, mainly simple sugars and carbohydrates
It was demonstrated that metformin led to a protective effect against the development of PD by different mechanisms including inhibition generation of -synuclein, production of oxidative stress, attenuation of mitochondrial dysfunction, and modulation of the autophagy process through the AMPK-dependent pathway
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The study found that the plasma circHECW2 level in MDD patients was significantly increased and was positively correlated with depression severity and anxiety symptoms
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