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The two most common MTHFR variants are: You can have one or both, and their effects vary from mild to more significant depending on the combination and your lifestyle, nutrition, and environmental exposures

Specifically, they are approved in patients who have a BMI 30 kg/m 2 or who have a BMI 27 kg/m 2 and an obesity-related health condition (eg, diabetes, hypertension, or dyslipidemia)

Here in the States, Wegovy manufacturer Novo Nordisk has filed for FDA approval of its injection to 7.2 mg and been approved as of March 19, 2026

These drugs work by increasing the release of insulin, reducing appetite, and slowing down the digestion process, which can lead to weight loss