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GLP-1+GIP dual-agonists - such as tirzepatide - add a second mechanism: mimicking GIP (glucose-dependent insulinotropic polypeptide), which targets additional hormonal pathways involved in appetite and blood sugar regulation
Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men
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Research from the International Society of Sports Nutrition examining body composition during weight loss shows that protein intake below 0.7g per pound results in accelerated muscle loss even with resistance training
It appears safe so far, but long-term data is still limited
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