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Data from the 2021 Nature Aging paper are particularly illuminating on this point
The cumulative impact is to make things more confusing to average consumers, who in this case just want to be their best selves and need clear guidance on what works in an arena filled with lots of anecdotes but not a lot of science
The answer is that it really depends, but in my experience, MOST patients are fine to use subcutaneous injection-sized needles
Some individuals may feel pain or swelling at the injection site
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