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Research from the STEP programme (semaglutide), SCALE studies (liraglutide), and SURMOUNT trials (tirzepatide) consistently demonstrates significant reductions in waist circumference, which correlates with abdominal fat loss
Fever above 100.4F (38C) should prompt evaluation, as this is not an expected side effect of tirzepatide and more likely represents an infectious process requiring diagnosis and treatment
Recent observational studies and meta-analyses (2020-2024) have generally not confirmed an increased risk of pancreatitis with GLP-1 receptor agonists
doi: 10.1172/jci.insight.133429 3 JensterleMJaneA
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