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One of the biggest names to watch is retatrutide, being developed by Eli Lilly, the same company that makes Mounjaro and Zepbound
The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism remains unsettled
10.3389/fnut.2021.748433 11 BouranisJ
They are also a great source of polyphenols that support liver cleansing
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