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[1] [5] These gastrointestinal effects typically diminish over time as the body adjusts to the medication

doi: 10.1016/j.yexmp.2021.104617 276 YangXLiJWuYNiBZhangB

Despite the exposure of mitochondria to the production of oxidants, the presence of an effective antioxidant system, of which mitochondrial GSH (mGSH) is a key component, prevents or repairs oxidative damage that occurs during normal aerobic metabolism [57]