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This activation mobilizes stored triglycerides within hepatocytes for oxidation, effectively decreasing hepatic lipid content ( de novo lipogenesis while promoting lipid catabolism, resulting in a net reduction of hepatic steatosis ( In summary, this dual mechanism addresses the fundamental lipid dysregulation in MASLD by restoring the balance between lipid synthesis and degradation within the liver, thereby mitigating steatosis and its metabolic consequences ( 3.2.3 Anti-inflammatory and anti-fibrotic effects Activation of GLP-1 receptors by dual agonists exerts potent anti-inflammatory effects within the liver microenvironment, which are crucial for preventing progression from steatosis to steatohepatitis and fibrosis
Achadu O
Chem Res Toxicol 25(8):16161632 Tirmenstein MA, Nelson SD (1989) Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3-hydroxyacetanilide, in mouse liver
Increases regenerative functions of nerve tissues
