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Similar content being viewed by others Introduction Maintenance of mitochondrial function and adaptation to changes in nutritional state is vital for the preservation of pancreatic -cell regulated secretion of insulin 1 , the main hormone in charge of lowering blood glucose concentrations, with disruptions in this process underlying the development and/or progression of type 2 diabetes (T2D) 1,2 an uncontrolled pandemic affecting 500 million people worldwide, and causing 1.5 million deaths per year 3
Additionally, the gastrointestinal effects of semaglutideincluding nausea and reduced appetitemay lead to dehydration or altered eating patterns, which are recognised headache triggers
Factors such as diet, age, sex, and metabolic status have not been fully controlled
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