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The new indication could give Novo Nordisk a boost against rivals in the GLP-1 agonist class, including Eli Lilly, whose dual GIP/GLP-1 agonist Mounjaro (tirzepatide) competes in the diabetes category and is in a phase 3 trial (TREASURE-CKD) looking at a CKD indication in people with obesity, with and without diabetes
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After drug treatment in MAFLD rats, there was a decrease in the enrichment of Retinol metabolism. These pathway alterations may contribute to the reduced fat accumulation
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