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For localised pain, topical NSAIDs are a useful alternative that avoids most of the stomach and kidney risks
Importantly, these medications lead to a considerable reduction of cardiovascular morbidity 21 and population-level all-cause mortality 22
The route is subcutaneous injection with a small insulin-size needle, usually into the abdomen or thigh, with daily site rotation
Abel ED, Gloyn AL, Evans-Molina C, Joseph JJ, Misra S, Pajvani UB, Simcox J, Susztak K, Drucker DJ
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