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This focus led to significant breakthroughs, but it became clear in animal models that single-pathway stimulation had a ceiling effect regarding metabolic stabilization and lipid management
7,8,9 The 2024 Dao study of 168 first-trimester GLP-1 exposures and the 2024 Cesta study of 938 periconceptional GLP-1 exposures both found no significant increase in major birth defects
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