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When pain is detected, serotonergic neurons in the brainstem (in a region called the rostral ventromedial medulla) are activated and release serotonin
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Patients who have experienced allergic reactions to other GLP-1 receptor agonists should exercise extreme caution and may need to avoid this medication entirely, as cross-reactivity between different GLP-1 receptor agonists is possible
Patient population stratification: which patients will benefit most (frail older, endocrine decline, metabolic syndrome)
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