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Phase 2 trial data (Jastreboff et al., NEJM, 2023) showed mean body weight reductions of approximately 24% at 48 weeks with the highest dose, with no clear plateau observed
For many individuals, this occurs at 7.5 to 10 mg weekly
The cyclic structure is maintained by the disulfide bond, which is susceptible to oxidative cleavage in the presence of dissolved oxygen, light exposure, and temperatures above 8C
Connective Tissue Growth Factor (CTGF) Is Essential for Self Renewal and Proliferation of Mesenchymal Stromal cells (MSCs) and Affects Leukemia-Stromal Interactions
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