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doi: 10.1210/jc.2014-2547 26 HelstedMMGasbjergLSLanngARBergmannNCStensenSHartmannBet al

What makes tirzepatide different from earlier medications in this class is that it doesnt just target one hormone pathway, it targets two: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Starting doses of 0.25mg weekly are reported for the first four weeks, escalating to 0.5mg for weeks five through eight, then 1.0mg for weeks nine through twelve, reaching maintenance doses of 1.7mg or 2.4mg weekly thereafter

But doctors noticed something interesting in the early users of GLP-1 receptor agonists: not only did their diabetic symptoms reverse, but they were also losing weight