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Retatrutide may be suitable for adults who: Have a body mass index (BMI) of 27 or higher Struggle with weight management despite diet and exercise efforts Have type 2 diabetes Do not have a personal or family history of certain medical conditions or allergies Semaglutide may be suitable for adults who: Have a BMI of 30 or higher BMI of 27 or higher with weight-related conditions, such as type 2 diabetes, high blood pressure, or high cholesterol Struggle with weight management, mainly if youve had limited success with diet and exercise alone