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Side Effects and Safety Across all published research, ipamorelin has demonstrated a favorable safety profile: No significant cortisol or prolactin elevation at therapeutic doses No meaningful appetite stimulation Mild and transient side effects including headache, flushing, and injection site irritation No serious adverse events reported in published clinical trials at standard doses The main limitation is the absence of long-term safety data from large-scale human studies
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Accordingly, several in vitro studies aimed at assessing the efficacy of drugs on glucose-related cell damage in ARPE-19 reported that using euglycemic media (5.5 mM) as a control condition may affect normal cell growth [48]
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