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Ridker et al., 2000), where the CANTOS study, for the first time, established reduced rates of cardiovascular events following an anti-interleukin-1 beta (IL-1) based therapy, independent of cholesterol levels (Ridker et al., 2017)
Statements These statements have not been evaluated by the Food and Drug Administration
Substance-use disorders Pre-clinical and mechanistic studies A large body of pre-clinical and mechanistic literature is available regarding the putative effects of GLP-1RAs on substance misuse (Supplementary Section 5): 24 for alcohol 59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82 , 8 for opiates 63,83,84,85,86,87,88,89 , 16 for stimulants, including cocaine and amphetamines 90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105 , and 4 for nicotine 106,107,108,109
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