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These objective measures can help demonstrate treatment benefits even when the scale changes more slowly than hoped
N-acetyl-L-cysteine enhances the osteogenic differentiation and inhibits the adipogenic differentiation through up regulation of Wnt 5a and down regulation of PPARG in bone marrow stromal cells
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These include elucidating underlying mechanisms, identifying reliable predictors of therapeutic response, and defining benefits in populations underrepresented or excluded from clinical trials [134,135]
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