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Treatment with human insulin does not increase thyroid cancer risk in patients with type 2 diabetes
This stress leads to suppression of forkhead box O1 (FoxO1) signaling and subsequent upregulation of thioredoxin interacting protein, inhibition of insulin and SOD-2 expression, re-expression of Neurog3, and -cell dedifferentiation and functional failure
doi: 10.1093/gerona/63.10.1027
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