In STEP 1 [1] , the largest trial with 1,961 participants [1] , patients receiving semaglutide 2.4 mg weekly achieved an average weight loss of 14.9% over 68 weeks, compared to 2.4% with placebo (Wilding et al., NEJM, 2021)

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Slowing the breakdown and absorption of dietary carbohydrates, so glucose enters the bloodstream more gradually
Because digestion is slowed, large or heavy meals tend to sit longer in the stomach, making symptoms more noticeable