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doi: 10.1016/j.lfs.2020.118986 83 LiangWZhouKJianPChangZZhangQLiuYet al

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Change from Baseline in A1C at Week 26 with Alogliptin and Pioglitazone Alone and Alogliptin in Combination with Pioglitazone when Added to Metformin Alogliptin Add-On Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on Metformin in Combination with Pioglitazone In a 52 week, active-comparator study, a total of 803 patients inadequately controlled (mean baseline A1C = 8.2%) on a current regimen of pioglitazone 30 mg and metformin at least 1500 mg per day or at the maximum tolerated dose were randomized to either receive the addition of alogliptin 25 mg or the titration of pioglitazone 30 mg to 45 mg following a four week, single-blind, placebo run-in period