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10.1021/cr300163e 269 PerriE
GLP-1R protein has also been detected in human coronary artery endothelial cells (HCAEC) and human umbilical vein endothelial cells (HUVEC) [33],[34]
Early Evidence In the latest GLP-1 study 2025 , orforglipron showed early promise for adults with obesity and those living with type 2 diabetes, especially at the highest evaluated dose
The retatrutide phase 2 body-composition substudy showed lean-mass loss in line with the total weight loss, without evidence of the medication causing extra lean mass losses
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