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when present, symptoms typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders rather than the high B12 itself
Additionally, the expression of proteins involved in the metabolism of other sugars was downregulated giving the bacteria a selective advantage for preferential utilization of simple sugars and thus to shut down the redundant metabolic processes
doi: 10.1007/s00281-019-00733-8 92 SatoKSuematsuAOkamotoKYamaguchiAMorishitaYKadonoYet al
Metabolic vulnerabilities are being exploited through combinations such as sirolimus (an mTOR inhibitor) and auranofin (a thioredoxin reductase inhibitor) in advanced NSCLC and SCLC (NCT01737502)
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