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Striking the Balance of GLP-1 and Glucagon Agonism to Minimise Potential Risks Based on outcomes from safety and pharmacokinetic studies with GLP-1 analogues, the most common side effect observed with GLP-1 agonism is dose-dependent nausea and vomiting ( Even with careful engineering of receptor balance, potency and pharmacokinetics, problems may still crop up, as illustrated by SAR425899s unexpected development failure due to excessive gastrointestinal adverse events during its Phase 2 trials
"Semaglutide and very-low calorie diet combo shows superior results in managing type 2 diabetes"
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