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"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes

So the deciding factor is not pharmacology, it is ergonomics, and the ergonomics of a bedtime injection are specific: you are already sitting on the edge of the bed, the room lights are low, and you want the whole thing over in ninety seconds so you can lie down

Changes in subtypes of overt thyrotoxicosis and hypothyroidism following iodine fortification