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The research team of Frias et al designed a 32-week, randomized, double-blind, parallel-group, active control trial that included adults with a diagnosis of type 2 diabetes and a body mass index of 27 and HbA1C levels ranging from 7.5% to 10% despite a daily dose of metformin

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Although extremely costly and time-consuming, these outcome trials have, nevertheless, provided us with extremely valuable information about the natural history of the diseases, drug safety and the influence of the drugs on the disease progression