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May 2024;46(5):404-410
The introduction of the R17 Cagri- E14 Cagri intra-peptide ionic lock energetically favours the formation of a predominant bypass conformation at the CTR, which, together with the P37 substitution and the effects induced by the N-terminal acylation, likely underlies its improved potency over rAmy at this receptor
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Furthermore, the systemic neuroinflammation driven by this oxidative stress directly impacts the autonomic nervous system
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