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191 For instance, WEE1 inhibition (e.g., with AZD1775) abrogates G2/M checkpoints, thereby potentiating the cytotoxicity of DNA-damaging agents such as cisplatin
[20] Both subunits of the GST dimer, whether hetero- or homodimeric in nature, contain a single nonsubstrate binding site, as well as a GSH-binding site
discovered a non-lethal inhibitor drug 3,3-dimethyl-1-butanol (DMB)which can promote the formation of endogenous macrophage foam cells and the development of atherosclerotic lesions in ApoE / mice without changing circulating cholesterol levels (75)
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