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3 However, the active forms of GLP-1 have a very short plasma half-life (less than 2 minutes) due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)
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Aono S, Yamada Y, Keino H, Hanada N, Nakagawa T, Sasaoka Y et al
A 2023 systematic review noted that gastrointestinal side effects like constipation, nausea, and diarrhoea were more prevalent during the dose-escalation phase of tirzepatide, particularly in individuals who had pre-existing digestive sensitivities
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