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The SURPASS clinical trial program (type 2 diabetes) and SURMOUNT program (obesity/overweight) together represent one of the largest phase 3 development programs in metabolic medicine
While we cannot explain the discrepancy, the previous study mostly employed i) higher concentrations of Ex4 (520 g/kg) than used here (0.2 g/kg), subcutaneous delivery of Ex4 as their peripheral route, whereas we here employed i.p
Clinical Trial Limitations Interpreting the clinical data for both compounds requires careful consideration of study limitations and methodological differences
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