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23 The NAD + level can be elevated by dietary supplementation of NAD + precursors, such as Trp, NA, NMN and NR, inhibition of NAD + -consuming enzymes, including PARP1 and CD38, management of the NAD + biosynthesis via controlling NAD + -biosynthesis enzymes, or improving NAD + bioavailability through exercise and caloric restriction

SCF/\(\beta\)-Trcp promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

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