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In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia
Conversely, HT-1080 cells exposed to low doses of Fento-1 exhibited reduced CD44 and ferritin levels together with downregulated mesenchymal markers, which indicated that these cells adapt to lysosomal iron targeting (Fig
GLP-1 medications primarily work by reducing appetite and slowing gastric emptying
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