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The recent BMJ systematic review and meta-analysis that triggered many of these headlines is important and, frankly, not surprising to clinicians who understand obesity as a chronic, relapsing disease
8 Combination therapy considerations Although monotherapy remains the mainstay of epilepsy treatment, combination treatment with two or more AEDs may be necessary in some difficult to treat patients
J.PangM
Further research and appropriate regulatory evaluation are required before conclusions about clinical use can be drawn
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