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Dose, delivery, and brain absorption matter: Some GLP-1s are better absorbed and have more potential to improve cognitive endpoints than others Combination therapeutics may be required: GLP-1s may need to be paired with lifestyle interventions or complementary neuroprotective agents to produce measurable results in specific disease outcomes

Our analysis found that metformin showed the strongest potential to protect the brain, while semaglutide was among the least effective

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