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The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved

Most of the GSH (8085%) is stored in the cytosol, 1015% in the mitochondria (with an equal concentration between matrix and cytosol, thus requiring specific transport systems) and a small part in the endoplasmic reticulum (ER) ( 2.1

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