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The Sugimoto 1995 study documented that copper ions inhibit type 1 5-alpha reductase by up to 90% in vitro, with 50% inhibition at 0.12 mcg copper/mL

Genetics are often the primary driver of premature graying but environment and lifestyle factors also play a role and can accelerate it. While optimizing glutathione and antioxidant levels can help, Lee said it wont compensate for systemic poor health including smoking, high alcohol intake and processed food-heavy diets

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Inflammation modulation is evident by reduced pro-inflammatory cytokine expression in injured sites, shortening the inflammatory phase of healing