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To test this, scientists used an exercise-challenge model in both rodents and humans to induce inflammation and evaluate whether the ability of L-carnitine tartrate to downregulate ACE2 expression could translate to an attenuation of SARS-CoV-2 infectivity in an in vitro human lung epithelial cell-based system 5

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We found that T3 treatment decreased the total percentage of BAs with TGR5 agonist activities in the ileum of MMI mice, while the percentage of DCA, which is abundant in ileum and exhibits potent TGR5 agonist activity, was not altered (Supplementary Fig