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3.3 Mitochondrial dysfunction and oxidative stress Chronic hyperglycemia in patients with T2DM leads to peripheral insulin resistance, whereas impaired insulin signaling pathways in the brains of patients with AD lead to brain insulin resistance, both of which are closely related to mitochondrial dysfunction and OS (Zhang et al., 2023)

Indeed, obese mice with leptin or leptin-receptor deficiency showed no increase in arterial pressure (Mark et al., 1999)

AACE Clinical Case Reports 4(3):199202 Jrvinen A et al (2019) Beneficial effects of GLP-1 agonist in a male with compulsive food-related behavior associated with autism

95% CI, 0.37-0.81), the researchers found