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The therapeutic efficacy against TNBC can be improved using tumour microenvironment-responsive nanoparticles and epigenetic reprogramming [152]
Factors affecting individual clearance Multiple factors influence how quickly peptides clear from your system: Body composition: Higher body fat may affect distribution and clearance of some compounds Kidney function: Renal clearance is the primary elimination pathway for most peptides Hydration status: Affects urine concentration and potentially detection thresholds Dosage: Higher doses require longer clearance times Frequency of use: Chronic use may result in accumulation Administration route: Injectable, oral, and nasal routes have different pharmacokinetics These factors create significant individual variation
MOTS-c has poor oral bioavailability due to peptide bond degradation in the gastrointestinal tract
Magen, Eli (2014)
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